Understanding the role of Rac1
Rac1 GTPase and its variants are proteins that function as central signaling nodes for diverse pathways that drive various cancer promoting processes including cell growth, migration, invasion, and angiogenesis. These proteins switch between the inactive guanosine diphosphate (or GDP-bound form) and the active guanosine triphosphate (or GTP-bound form) which recruits other downstream effector proteins to activate oncogenic pathways.
While GTPases have been elusive to targeted drug discovery, we have developed proprietary methods to target these signaling proteins, including high throughput screening methods. Currently, Revere is focused on Rac1 and its variants and Cdc42, a closely related Rho GTPase.