Revere Pharmaceuticals | Rac1 GTPase

Publications by Revere authors

Sun, J., Gaidosh, G, Xu, Y, Mookhtiar, A, Goka, ET, Lippman, ME, et al. RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells. Oncogene. 2021.

Goka, ET, Mesa Lopez, DT, Lippman, ME. Hormone dependent prostate cancers are dependent on Rac signaling for growth and survival. Mol Cancer Ther. 2021; 20(6): 1052-1061.

Goka, ET, Chaturvedi, P, Mesa Lopez, DT, Lippman, ME. Rac signaling drives clear cell renal cell carcinoma tumor growth by priming the tumor microenvironment for an angiogenic switch. Mol Cancer Ther. 2020; 19(7): 1462-1473.

Goka, ET, Chaturvedi, P, Mesa Lopez, DT, De La Garza, A, Lippman, ME. Rac1b overexpression confers resistance to chemotherapy treatment in colorectal cancer. Mol Cancer Ther. 2019; 10(5):,957-968.

Goka, ET, Lippman, ME. Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression. Oncogene. 2016; 34(42): 5395-5405.

Rac1 Cancer Reviews

De, P, Rozenboom, BJ, Aske, JC, Dey, N. Active RAC1 promotes tumorigenic phenotypes and therapy resistance in solid tumors. Cancers. 2020; 12: 1541.

De, P, Aske, JC, Dey, N. RAC1 takes the lead in solid tumors. Cells. 2019; 8(5): 382.

Casado-Medrano, V, Baker, MJ, Lopez-Haber, C, et al. The role of Rac in tumor susceptibility and disease progression: From biochemistry to the clinic. Biochemical Society Transactions. 2018; 46: 1003-1012.

Del Mar Maldonado, M, Dharmawardhane, S. Targeting Rac and Cdc42 GTPases in cancer. Cancer Res. 2018; 78(12): 3101-3011.

Kazanietz, MG, Caloca, MJ. The Rac GTPase in cancer: From old concepts to new paradigms. Cancer Res. 2017; 77(20): 5445-5451.

Bid, HK, Roberts, RD, Manchanda, PK, Houghton, PJ. RAC1: An emerging therapeutic option for targeting cancer angiogenesis and metastasis. Mol Cancer Ther. 2013; 12(10): 1925–34.

Rac1/Cdc42 in Coronavirus Infection

Wen, Z, Zhang, Y, Lin, Z, et al. Cytoskeleton—a crucial key in host cell for coronavirus infection. J Mol Cell Biol. 2020; 12(12): 968-979.

Swaine, T and Dittmar, MT. Cdc42 use in viral cell entry processes by RNA viruses. Viruses. 2015; 7: 6526-6536.

Freeman, MC, Peek, CT, Becker, MM. et al. Coronaviruses induce entry-independent, continuous micropinocytosis. mBio. 2014; 5(4).

Rac1 in CKD

Patel, S, Tang, J, Overstreet, JM et al. Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways. FASEB J. 2019; 33: 9797-9810.

Robins, R, Baldwin, C, Aoudjit, L, et al. Rac1 activation in podocytes induces the spectrum of nephrotic syndrome. Kidney Intl. 2017; 92: 349–364.

Nagase, M, Fujita, T. Role of Rac1–mineralocorticoid-receptor signalling in renal and cardiac disease. Nat Rev Nephrol. 2013; 9: 86–98.

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Publications by Revere authors

Rac1 Cancer Reviews

Rac1/Cdc42 in Coronavirus Infection

Rac1 in CKD

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